Not to be taken by pregnant or lactating women. At this time, there are no known side effects or precautions.

Consult your physician for more information.

The capacity for grapefruit seed extract to produce drug interactions remains unknown. Like all botanical products,

grapefruit seed extract is a complex material with numerous phytochemicals that remain largely uncharacterized with respect to drug pharmacokinetics. Human studies have established that two furanocoumarins, bergamottin and 6,7-dihydroxybergamottin (DHB), are primarily responsible for drug interactions with grapefruit juice. An 8-ounce glass of grapefruit juice contains typically contains 1-2 mg bergamottin and 2-3 mg DHB. HPLC analysis revealed less than 0.1 mg/g bergamottin and 2.99 mg/g DHB in Pure Encapsulations grapefruit seed extract. The effective dose range for the seed in promoting microbial balance is 250-1,000 mg, which yields 0.75-2.99 mg DHB and less than 0.025-0.1 mg bergamottin per day. Therefore, 4 capsules of our seed extract falls below the range associated with bergamottin-mediated events, but is within the range of DHBassociated drug interactions. The negligible bergamottin suggests this extract does not recapitulate completely the negative effects of grapefruit juice and should be regarded

as a distinct seed material. Consult your physician for more information.